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Prophylactic Antibiotic Regimen Selection For Surgery
Version 2010B

Prophylactic Antibiotic Regimen Selection For Surgery

Surgical Procedure Approved Antibiotics
CABG, Other Cardiac or Vascular Cefazolin, Cefuroxime Appendix C Table 3.1
or Vancomycin** Appendix C Table 3.8
If β-lactam allergy: Vancomycin* Appendix C Table 3.8 or Clindamycin* Appendix C Table 3.9
Hip/Knee Arthroplasty Cefazolin or Cefuroxime Appendix C Table 3.2
or Vancomycin** Appendix C Table 3.8
If β-lactam allergy: Vancomycin* Appendix C Table 3.8 or Clindamycin* Appendix C Table 3.9
Colon Cefotetan, Cefoxitin, Ampicillin/Sulbactam Appendix C Table 3.5, or Ertapenem† Appendix C Table 3.6b
OR
Cefazolin or Cefuroxime Appendix C Table 3.2 + Metronidazole Appendix C Table 3.6a

If β-lactam allergy:
Clindamycin Appendix C Table 3.9 + Aminoglycoside Appendix C Table 2.11 ,
or Clindamycin Appendix C Table 3.9 + Quinolone Appendix C Table 3.12,
or Clindamycin Appendix C Table 3.9 + Aztreonam Appendix C Table 2.7
OR
Metronidazole Appendix C Table 3.6a with Aminoglycoside Appendix C Table 2.11,
or Metronidazole Appendix C Table 3.6a + Quinolone Appendix C Table 3.12
Hysterectomy Cefotetan, Cefazolin, Cefoxitin, Cefuroxime,
or Ampicillin/Sulbactam Appendix C Table 3.7

If β-lactam allergy: Clindamycin Appendix C Table 3.9 OR
Metronidazole Appendix C Table 3.6a
Special Considerations * For cardiac, orthopedic, and vascular surgery, if the patient is allergic to β-lactam antibiotics, Vancomycin or Clindamycin are acceptable substitutes.
**Vancomycin is acceptable with a physician/APN/PA documented justification for its use (see data element Vancomycin)
† A single dose of ertapenem is recommended for colon procedures.

See Appendix C: Medication Tables.

Prophylactic Antibiotic Regimen Selection For Surgery
Specifications Manual for Joint Commission National Quality Core Measures (2010B)
Discharges 10-01-10 (4Q10) through 03-31-11 (1Q11)