| Section | Rationale | Description |
|---|---|---|
| ALC-01 | Rationale updated to reflect updated references | Rationale
Change from:
Nearly two out of five individuals in assisted living are living with some type of dementia. For these individuals and as illness progresses, behavior often becomes a key form of communication. This can be challenging for families and staff, and too often, antipsychotic medication is used in an attempt to modify behavior. To: Nearly two out of five individuals in assisted living are living with some type of dementia. (American Health Care Association/National Center for Assisted Living [AHCA/NCAL], 2024). For these individuals and as illness progresses, behavior often becomes a key form of communication. This can be challenging for families and staff, and too often, antipsychotic medication is used in an attempt to modify behavior. Change from: The use of antipsychotic medication to treat behavior associated with dementia is not supported clinically and is considered off-label by the FDA, which issued a “black box” warning for the elderly with dementia. They increase the risk of death, falls and fractures, hospitalizations, and other complications resulting in poor health and high costs. Additionally, antipsychotic drugs are expensive, costing Medicare hundreds of millions. American Health Care Association/National Center for Assisted Living (AHCA/NCAL). https://www.ahcancal.org/Assisted-Living/About-NCAL/Pages/default.aspxTo: The American Geriatrics Society Beers Criteria® Update Expert Panel (2023) continues to stress the need to avoid antipsychotics and other medications for behavioral problems of dementia and delirium as their use is frequently associated with harm. The use of antipsychotic medication to treat behavior associated with dementia is not supported clinically and is considered off-label by the FDA, which issued a “black box” warning for the elderly with dementia (Rashid et al., 2022). They increase the risk of death, falls and fractures, hospitalizations, and other complications resulting in poor health and high costs. (American Geriatrics Society Beers Criteria® Update Expert Panel, 2023). Selected References Change from:
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| ALC-02 | Rationale updated to reflect updated references | Rationale
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(CDC, 2016) To: (Centers for Disease Control and Prevention [CDC], 2025) Change from:(CDC, 2024) To: (CDC, 2026) Selected references Change from:
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| ALC-03 | Rationale updated to reflect updated references | Rationale
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(Institute for Healthcare Improvement, n.d.). Selected references Change from:
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| ALC-04 | Rationale updated to reflect updated references | Rationale
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(NQF 2006; IOM, 2014; Yadav et al., 2017) To: (Kim et al., 2025) Selected references Remove:
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| ALC-05 | Rationale updated to reflect updated references | Rationale
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American Health Care Association/National Center for Assisted Living (AHCA/NCAL)https://www.ahcancal.org/Workforce-and-Career/Pages/Organizations.aspx Add:(Li et al., 2021) Add:(American Health Care Association/National Center for Assisted Living, n.d.) Selected references Add:
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| Section | Rationale | Description |
|---|---|---|
| Off-Label Antipsychotic Drug Prescribed | Antipsychotics Table updated to reflect medications no longer available, new FDA approvals or updates based on PharmD review. | Antipsychotic Table
Loxitane/Adusave/(Loxapine) Remove:Adasave Thorazine (Chlorpromazine) ADD:acute intermittent porphyria (nausea, vomiting, and psychiatric symptoms associated with this disease) Compro (Prochlorperazine) Change from:General Anxiety Disorder To: management of anxiety Clozaril/Fazaclo/Versacloz (Clozapine) Change from:Schizophrenia To: Treatment resistant schizophrenia Seroquel/Seroquel XR (Quetiapine) Change from:Major Depressive Disorder To: adjunctive treatment of major depressive disorder Risperdal/Risperda Consta/Perseris/Uzedy (Risperidone) Change from:Bipolar Disorder acute mania/acute episodes with mixed features/maintenance (PO, IM) To:Bipolar Disorder acute mania/acute episodes with mixed features/maintenance (PO, IM, SQ) Caplyta (Lumateperone) Add:Major Depressive Disorder, as adjunct to antidepressants (PO) Latuda (Lurasidone) Change from:bipolar To:bipolar 1 disorder Add:Bysanti (milsaperidone) - Bipolar I disorder (acute treatment of manic or mixed episode) (PO) Schizophrenia (PO) |
| Section | Rationale | Description |
|---|---|---|
| No Supplemental Material release notes for the ALC2027A release. | ||